Plot no 105, Part A, Karnataka Industrial Area Development Board, Humnabad, Karnataka 585330

1,2,3,9-Tetrahydrocarbazolone (1,2,3,9-Tetrahydro-4H-carbazol-4-one) Manufacturer India

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1,2,3,9-Tetrahydro-4H-carbazol-4-one (CAS 15128-52-6). A Versatile Heterocyclic Building Block for Carvedilol and Ondansetron APIs.

Chemical Structure of 1,2,3,9-Tetrahydro-4H-carbazol-4-one

1,2,3,9-Tetrahydrocarbazolone (Carbazolone)

CAS No: 15128-52-6

A high-purity carbazole derivative (commonly known as 1,2,3,9-tetrahydro-4H-carbazol-4-one, 4-Oxo-1,2,3,4-tetrahydrocarbazole, or 1,2,3,4-Tetrahydrocarbazol-4-one) essential for the synthesis of complex pharmaceutical compounds.

This compound is widely utilized as a key starting material (KSM) in the manufacturing of Ondansetron (anti-emetic) and Carvedilol (beta-blocker). Kalpasthana Life Care Products ensures premium purity standards for this intermediate.

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Product Specifications

Product Name 1,2,3,9-Tetrahydrocarbazolone
Synonyms / Abbreviations 1,2,3,9-Tetrahydro-4H-carbazol-4-one, 4-Oxo-1,2,3,4-tetrahydrocarbazole, Carbazolone, Ondansetron Intermediate
CAS Number 15128-52-6
Molecular Formula C12H11NO
Molecular Weight 185.22 g/mol
Appearance Off-white to Pale Yellow Powder
Purity (HPLC) ≥ 99.0%
Melting Point 220°C - 225°C

Applications & Usage

This compound is a highly versatile heterocyclic intermediate. It serves as the primary starting material for the synthesis of Ondansetron (a critical 5-HT3 receptor antagonist for chemotherapy-induced nausea) and acts as an intermediate pathway to 4-hydroxycarbazole for Carvedilol API production. Additionally, it finds application in the synthesis of other carbazole-based pharmaceuticals like Alosetron and high-performance optoelectronic polymers.

Key Features

  • Heterocyclic Building Block: A critical precursor for Borsche–Drechsel cyclization and Fischer Indole derivatives.
  • Multi-API Sourcing: Supports commercial manufacturing lines for anti-emetics (Ondansetron, Alosetron) and cardiovascular therapies (Carvedilol).
  • Polymer & Material Science: Used in the synthesis of photoconductive carbazole polymers and light-emitting materials.

Product Specifications & Procurement FAQs

Detailed quality specifications, compliance data, and procurement answers for pharma sourcing professionals.

Quality & Technical Specifications

Chemical Synonyms Tetrahydrocarbazolone, 1,2,3,9-tetrahydro-carbazol-4-one, Ondansetron precursor, Carvedilol precursor
Manufacturing Location Kalpasthana Life Care Products, Plot no 105, Part A, KIADB Industrial Area, Humnabad, Bidar District, Karnataka, India - 585330
Compliance & Quality GMP-compliant state-of-the-art facility, rigorous HPLC purity standards ≥99.0%.
Commercial Packaging Standard 25 kg HDPE fiber drums with double polythene inner bags; custom B2B packaging available.

Frequently Asked Questions

What is the primary role of 1,2,3,9-Tetrahydrocarbazol-4-one (CAS 15128-52-6) in API manufacturing?

1,2,3,9-Tetrahydrocarbazol-4-one (often referred to as Tetrahydrocarbazolone) is a critical dual-use pharmaceutical intermediate. It is most notably utilized as a key precursor in the synthesis of the anti-emetic drug Ondansetron (Zofran) and the anti-hypertensive agent Carvedilol. Sourcing a high-purity intermediate is crucial to optimize downstream reaction yields and minimize process impurities.

What are the specifications and quality compliance standards for bulk sourcing of 1,2,3,9-Tetrahydrocarbazol-4-one?

Our commercial-grade 1,2,3,9-Tetrahydrocarbazol-4-one is manufactured under strict quality controls, maintaining an HPLC purity of ≥99.0%. We provide complete regulatory documentation for B2B compliance, including Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), gas chromatography profiles, and impurity reports.

What are the packaging, storage guidelines, and transport logistics for bulk Tetrahydrocarbazolone?

The standard bulk commercial packaging for 1,2,3,9-Tetrahydrocarbazol-4-one is 25 kg HDPE fiber drums with double sealed polythene inner liners. It should be stored in a cool, dry, well-ventilated warehouse away from strong oxidizing agents. Kalpasthana handles worldwide logistics with certified hazardous material transport compliance.

Technical Profile & Sourcing Guide

Comprehensive chemical specs, catalytic pathways, and quality compliance guidelines for raw materials sourcing.

Chemical Synthesis

1,2,3,9-Tetrahydrocarbazolone (1,2,3,9-tetrahydro-4H-carbazol-4-one) is a key heterocyclic ketone. It is synthesized via the Borsch-Drechsel cyclization (a modified Fischer Indole Synthesis) by reacting 1,3-cyclohexanedione with phenylhydrazine hydrochloride in an acidic medium, followed by crystallization.

Applications & Pathways

This compound is the primary Key Starting Material (KSM) for the anti-emetic drug Ondansetron. It undergoes methylation at the nitrogen atom to form 9-methyl carbazolone, which is then subjected to a Mannich reaction followed by imidazole substitution to yield Ondansetron.

Quality & Compliance

Our 1,2,3,9-Tetrahydrocarbazolone has a purity of >=99.0% by HPLC.

Storage & Packaging

It is a light beige to off-white crystalline solid, stored in standard 25 kg fiber drums under dry, cool conditions.

Safety & Protocols

Handle in a well-ventilated area to maintain stability and prevent degradation. Wear protective gloves and safety goggles.

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