1,2,3,9-Tetrahydrocarbazolone
1,2,3,9-Tetrahydro-4H-carbazol-4-one (CAS 15128-52-6). A Versatile Heterocyclic Building Block for Carvedilol and Ondansetron APIs.
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1,2,3,9-Tetrahydro-4H-carbazol-4-one (CAS 15128-52-6). A Versatile Heterocyclic Building Block for Carvedilol and Ondansetron APIs.
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1,2,3,9-Tetrahydrocarbazolone is a premium organic chemical synthesis intermediate, widely recognized as a crucial Key Starting Material (KSM) in B2B pharmaceutical manufacturing.
It is primarily utilized in the synthesis of Ondansetron, a key 5-HT3 receptor antagonist, and as a precursor to 4-hydroxycarbazole for Carvedilol active pharmaceutical ingredients. Sourcing this pharmaceutical intermediate from Kalpasthana ensures a high-purity product (>=99.0% by HPLC) that meets international quality standards. Sourcing directly from an established API Intermediate Manufacturer in India minimizes production bottlenecks and ensures reliable commercial scale manufacturing of bulk pharmaceutical chemicals.
Sourced directly from our state-of-the-art facility in Bidar District, Karnataka. Every batch is manufactured under strict quality controlled guidelines, ensuring predictable synthesis yields and batch-to-batch consistency.
This compound is a highly versatile heterocyclic intermediate. It serves as the primary starting material for the synthesis of Ondansetron (a critical 5-HT3 receptor antagonist for chemotherapy-induced nausea) and acts as an intermediate pathway to 4-hydroxycarbazole for Carvedilol API production. Additionally, it finds application in the synthesis of other carbazole-based pharmaceuticals like Alosetron and high-performance optoelectronic polymers.
In commercial pharmaceutical manufacturing, this carbazole derivative is crucial because it provides the pre-formed tricyclic tetrahydrocarbazole core. Sourcing this molecule in high purity (>=99.0%) prevents the carry-over of related heterocyclic impurities, significantly improving downstream crystallization yields during the synthesis of Ondansetron and related anti-emetics.
A critical precursor for Borsche–Drechsel cyclization and Fischer Indole derivatives, forming the tricyclic carbazolone core essential for multiple API synthesis pathways.
Supports commercial manufacturing lines for anti-emetics (Ondansetron, Alosetron) and cardiovascular therapies (Carvedilol) from a single high-purity intermediate.
Used in the synthesis of photoconductive carbazole polymers and light-emitting materials for advanced optoelectronic applications.
For 1,2,3,9-Tetrahydrocarbazolone, quality is our foundational pillar. We ensure high-purity tricyclic tetrahydrocarbazole footprints through strict process controls and specialized crystallization techniques at our Karnataka facility. Our laboratory specifically monitors organic synthesis pathways to limit related heterocyclic impurities and guarantee predictable batch yields for anti-emetic API synthesis.
Every commercial shipment of this Ondansetron intermediate is backed by rigorous HPLC assay verification (maintaining purity >=99.0%), GC-MS impurity profiling, and complete Certificates of Analysis (COA) to support B2B audit compliance.
Manufactured under strict GMP-compliant standard operating procedures ensuring batch-to-batch reproducibility and regulatory compliance.
In-house analytical testing ensuring HPLC purity >=99.0% for every batch, with full traceability and audit-ready documentation.
Complete B2B regulatory paperwork, technical dossiers, and audit support including COA, MSDS, and GC profiles.
Synthesized via the Borsch-Drechsel cyclization (a modified Fischer Indole Synthesis) by reacting 1,3-cyclohexanedione with phenylhydrazine hydrochloride in an acidic medium, followed by crystallization.
This compound is the primary Key Starting Material (KSM) for the anti-emetic drug Ondansetron. It undergoes methylation at the nitrogen atom to form 9-methyl carbazolone, which is then subjected to a Mannich reaction followed by imidazole substitution to yield Ondansetron.
Our 1,2,3,9-Tetrahydrocarbazolone has a purity of >=99.0% by HPLC, verified by in-house analytical testing for every commercial batch.
A light beige to off-white crystalline solid, stored in standard 25 kg fiber drums under dry, cool conditions to maintain stability.
Handle in a well-ventilated area to maintain stability and prevent degradation. Wear protective gloves and safety goggles during handling.
Global pharmaceutical sourcing teams partner with Kalpasthana due to our chemical manufacturing expertise, infrastructure reliability, and strict compliance alignment:
HPLC purity verified at >=99.0% with minimal related substances for every commercial batch of 1,2,3,9-Tetrahydrocarbazolone.
Continuous commercial-scale volume manufacturing capacity ensuring uninterrupted supply for global B2B pharmaceutical clients.
Complete analytical profiles, GC profiles, MSDS, and COA dossiers provided for every batch to support global regulatory audits.
Equipped with a 50 kL combined reactor volume at our GMP-compliant facility in Karnataka, India, ensuring scalable API intermediate manufacturing.
1,2,3,9-Tetrahydro-4H-carbazol-4-one • 4-Oxo-1,2,3,4-tetrahydrocarbazole • Carbazolone • Tetrahydrocarbazolone • Ondansetron Intermediate • Ondansetron KSM • Carvedilol Intermediate • Carvedilol Precursor • 2,3,4,9-Tetrahydro-1H-carbazol-4-one • 4H-Carbazol-4-one, 1,2,3,9-tetrahydro- • 1,2,3,9-Tetrahydrocarbazol-4-one • Carbazol-4(9H)-one, 1,2,3,9-tetrahydro-
Kalpasthana Life Care Products, Plot no 105, Part A, KIADB Industrial Area, Humnabad, Bidar District, Karnataka, India — 585330
GMP-compliant state-of-the-art facility, rigorous HPLC purity standards ≥99.0%.
Standard 25 kg HDPE fiber drums with double polythene inner bags; custom B2B packaging available.
This Ondansetron intermediate is indexed globally under CAS No. 15128-52-6. As a premium manufacturer, we serve as a major Ondansetron KSM (Key Starting Material) and Carvedilol intermediate supplier. We operate as a reliable Bulk Drug Intermediates supplier India partner, supplying bulk drug intermediates India and international clients trust. For orders or technical queries, contact Kalpasthana, a key partner for leading API supplier Hyderabad companies.
1,2,3,9-Tetrahydrocarbazol-4-one (often referred to as Tetrahydrocarbazolone) is a critical dual-use pharmaceutical intermediate. It is most notably utilized as a key precursor in the synthesis of the anti-emetic drug Ondansetron (Zofran) and the anti-hypertensive agent Carvedilol. Sourcing a high-purity intermediate is crucial to optimize downstream reaction yields and minimize process impurities.
Our commercial-grade 1,2,3,9-Tetrahydrocarbazol-4-one is manufactured under strict quality controls, maintaining an HPLC purity of ≥99.0%. We provide complete B2B documentation including COA, MSDS, GC profiles, and impurity report dossiers.
The standard bulk commercial packaging for 1,2,3,9-Tetrahydrocarbazol-4-one is 25 kg HDPE fiber drums with double sealed polythene inner liners. It should be stored in a cool, dry, well-ventilated warehouse away from strong oxidizing agents. Kalpasthana handles worldwide logistics with certified hazardous material transport compliance.
1,2,3,9-Tetrahydrocarbazolone is a premium organic chemical synthesis intermediate, widely recognized as a crucial Key Starting Material (KSM) in B2B pharmaceutical manufacturing. It is primarily utilized in the synthesis of Ondansetron, a key 5-HT3 receptor antagonist, and as a precursor to 4-hydroxycarbazole for Carvedilol active pharmaceutical ingredients. Sourcing this pharmaceutical intermediate from Kalpasthana ensures a high-purity product (>=99.0% by HPLC) that meets international quality standards. Sourcing directly from an established API Intermediate Manufacturer in India minimizes production bottlenecks and ensures reliable commercial scale manufacturing of bulk pharmaceutical chemicals.
Manufacturing Importance: Sourced directly from our state-of-the-art facility in Bidar District, Karnataka. Every batch is manufactured under strict quality controlled guidelines, ensuring predictable synthesis yields and batch-to-batch consistency.
This compound is a highly versatile heterocyclic intermediate. It serves as the primary starting material for the synthesis of Ondansetron (a critical 5-HT3 receptor antagonist for chemotherapy-induced nausea) and acts as an intermediate pathway to 4-hydroxycarbazole for Carvedilol API production. Additionally, it finds application in the synthesis of other carbazole-based pharmaceuticals like Alosetron and high-performance optoelectronic polymers.
In commercial pharmaceutical manufacturing, this carbazole derivative is crucial because it provides the pre-formed tricyclic tetrahydrocarbazole core. Sourcing this molecule in high purity (>=99.0%) prevents the carry-over of related heterocyclic impurities, significantly improving downstream crystallization yields during the synthesis of Ondansetron and related anti-emetics.
For 1,2,3,9-Tetrahydrocarbazolone, quality is our foundational pillar. We ensure high-purity tricyclic tetrahydrocarbazole footprints through strict process controls and specialized crystallization techniques at our Karnataka facility. Our laboratory specifically monitors organic synthesis pathways to limit related heterocyclic impurities and guarantee predictable batch yields for anti-emetic API synthesis.
Every commercial shipment of this Ondansetron intermediate is backed by rigorous HPLC assay verification (maintaining purity >=99.0%), GC-MS impurity profiling, and complete Certificates of Analysis (COA) to support B2B audit compliance.
Manufactured under strict GMP-compliant standard operating procedures.
In-house analytical testing ensuring HPLC purity >=99.0% for every batch.
Complete B2B regulatory paperwork, technical dossiers, and audit support.
Global pharmaceutical sourcing teams partner with Kalpasthana due to our chemical manufacturing expertise, infrastructure reliability, and strict compliance alignment:
1,2,3,9-Tetrahydrocarbazolone (1,2,3,9-tetrahydro-4H-carbazol-4-one) is a key heterocyclic ketone. It is synthesized via the Borsch-Drechsel cyclization (a modified Fischer Indole Synthesis) by reacting 1,3-cyclohexanedione with phenylhydrazine hydrochloride in an acidic medium, followed by crystallization.
This compound is the primary Key Starting Material (KSM) for the anti-emetic drug Ondansetron. It undergoes methylation at the nitrogen atom to form 9-methyl carbazolone, which is then subjected to a Mannich reaction followed by imidazole substitution to yield Ondansetron.
Our 1,2,3,9-Tetrahydrocarbazolone has a purity of >=99.0% by HPLC.
It is a light beige to off-white crystalline solid, stored in standard 25 kg fiber drums under dry, cool conditions.
Handle in a well-ventilated area to maintain stability and prevent degradation. Wear protective gloves and safety goggles.
| Chemical Synonyms | Tetrahydrocarbazolone • 1,2,3,9-Tetrahydro-4H-carbazol-4-one • 4-Oxo-1,2,3,4-tetrahydrocarbazole • Carbazolone • Ondansetron Intermediate • Ondansetron KSM • Carvedilol Intermediate • Carvedilol Precursor • 2,3,4,9-Tetrahydro-1H-carbazol-4-one • 1,2,3,9-Tetrahydrocarbazol-4-one • Carbazol-4(9H)-one, 1,2,3,9-tetrahydro- |
|---|---|
| Manufacturing Location | Kalpasthana Life Care Products, Plot no 105, Part A, KIADB Industrial Area, Humnabad, Bidar District, Karnataka, India - 585330 |
| Compliance & Quality | GMP-compliant state-of-the-art facility, rigorous HPLC purity standards ≥99.0%. |
| Commercial Packaging | Standard 25 kg HDPE fiber drums with double polythene inner bags; custom B2B packaging available. |
Commercial Sourcing & Synonyms: This Ondansetron intermediate is indexed globally under CAS No. 15128-52-6. As a premium manufacturer, we serve as a major Ondansetron KSM (Key Starting Material) and Carvedilol intermediate supplier. We operate as a reliable Bulk Drug Intermediates supplier India partner, supplying bulk drug intermediates India and international clients trust. For orders or technical queries, contact Kalpasthana, a key partner for leading API supplier Hyderabad companies.
1,2,3,9-Tetrahydrocarbazol-4-one (often referred to as Tetrahydrocarbazolone) is a critical dual-use pharmaceutical intermediate. It is most notably utilized as a key precursor in the synthesis of the anti-emetic drug Ondansetron (Zofran) and the anti-hypertensive agent Carvedilol. Sourcing a high-purity intermediate is crucial to optimize downstream reaction yields and minimize process impurities.
Our commercial-grade 1,2,3,9-Tetrahydrocarbazol-4-one is manufactured under strict quality controls, maintaining an HPLC purity of ≥99.0%. We provide complete regulatory documentation for B2B compliance, including Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), gas chromatography profiles, and impurity reports.
The standard bulk commercial packaging for 1,2,3,9-Tetrahydrocarbazol-4-one is 25 kg HDPE fiber drums with double sealed polythene inner liners. It should be stored in a cool, dry, well-ventilated warehouse away from strong oxidizing agents. Kalpasthana handles worldwide logistics with certified hazardous material transport compliance.
We are a leading API intermediate manufacturer in India, committed to delivering top-quality pharmaceutical and healthcare solutions globally.