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Methyl Adipoyl Chloride (CAS 2110-39-6) Manufacturer India

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High-Purity Methyl Adipoyl Chloride (Monomethyl Adipoyl Chloride). A premium ester acid chloride intermediate for selective organic synthesis and pharmaceutical manufacturing.

Chemical Structure of Methyl Adipoyl Chloride

Methyl Adipoyl Chloride

CAS No: 2110-39-6

A high-purity mono-ester acid chloride intermediate (commonly known as Methyl Adipoyl Chloride or Monomethyl Adipoyl Chloride) serving as a versatile and reactive building block for selective polymer synthesis, pharmaceutical derivatives, and fine chemicals.

Featuring both a highly reactive acid chloride group and a stable methyl ester group, this compound allows for selective mono-acylation and functionalization reactions. Kalpasthana Life Care Products manufactures premium grade Methyl Adipoyl Chloride under GMP-compliant protocols at our advanced Humnabad facility.

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Product Specifications

Product Name Methyl Adipoyl Chloride
Synonyms / Alternate Names Monomethyl adipoyl chloride, Methyl 5-(chlorocarbonyl)pentanoate, Adipic acid monomethyl ester chloride, Methyl 6-chloro-6-oxohexanoate, Monomethyl adipate acid chloride, Adipoyl chloride monomethyl ester
CAS Number 2110-39-6
Molecular Formula C7H11ClO3
Molecular Weight 178.61 g/mol
Appearance Colorless to light yellow liquid
Purity (GC) ≥ 98.0%
Boiling Point 110–113°C at 12 mmHg

Applications & Usage

Methyl Adipoyl Chloride (Methyl 5-(chlorocarbonyl)pentanoate) is a highly reactive asymmetric building block. It is the primary key intermediate for the commercial synthesis of Alpha Lipoic Acid (Thioctic Acid). The differential reactivity of the acid chloride end versus the protected methyl ester enables clean, selective mono-acylation and chain-extension reactions, making it vital in polymer modifying and API synthesis.

Key Features

  • Alpha Lipoic Acid Synthesis: Reacts selectively with ethylene and sulfur compounds to construct the core structure of Alpha Lipoic Acid.
  • Protected Ester Reactivity: Highly reactive carbonyl chloride allows rapid coupling while the methyl ester remains intact for subsequent steps.
  • Polymer Modifications: Used as an acylating agent to graft ester-terminated alkyl chains onto starch, cellulose, and high-performance polyamides.

Product Specifications & Procurement FAQs

Detailed quality specifications, compliance data, and procurement answers for pharma sourcing professionals.

Quality & Technical Specifications

Chemical Synonyms Monomethyl adipoyl chloride, Methyl 5-(chlorocarbonyl)pentanoate, Adipic acid monomethyl ester chloride, Methyl adipoyl chloride, Methyl 6-chloro-6-oxohexanoate, Monomethyl adipate acid chloride, Adipoyl chloride monomethyl ester
Manufacturing Location Kalpasthana Life Care Products, Humnabad, Bidar District, Karnataka, India - 585330
Compliance & Quality GMP-compliant state-of-the-art facility, rigorous GC and analytical purity testing.
Commercial Packaging Standard commercial plastic carboys / glass bottles with moisture-tight seals or customized B2B packaging.

Frequently Asked Questions

Why is Methyl Adipoyl Chloride preferred in selective acylation reactions?

Due to the differential reactivity between the highly reactive acid chloride group and the stable methyl ester. This allows chemists to selectively introduce the adipoyl moiety onto nucleophilic sites like amines or alcohols without side reactions or polymerization.

What are the storage and handling precautions for Methyl Adipoyl Chloride?

Methyl Adipoyl Chloride is moisture-sensitive and can release hydrogen chloride gas upon exposure to water or humidity. It must be stored in a cool, dry, well-ventilated area in tightly sealed, moisture-proof containers under dry nitrogen.

What documents are provided for regulatory compliance with Methyl Adipoyl Chloride?

Every commercial batch of Methyl Adipoyl Chloride is shipped with a Certificate of Analysis (COA) specifying GC purity, a comprehensive Material Safety Data Sheet (MSDS), technical specifications sheets, and batch production records as requested for your regulatory filings.

Technical Profile & Sourcing Guide

Comprehensive chemical specs, catalytic pathways, and quality compliance guidelines for raw materials sourcing.

Chemical Synthesis

Methyl Adipoyl Chloride (methyl 6-chloro-6-oxohexanoate) is a highly reactive acyl chloride. It is synthesized by the chlorination of monomethyl adipate using thionyl chloride or phosphorus trichloride, followed by vacuum distillation to ensure high purity and remove acidic gases. It is a moisture-sensitive, clear to light yellow liquid.

Applications & Pathways

As a reactive acylating agent, Methyl Adipoyl Chloride is a key raw material in the multi-step synthesis of Alpha Lipoic Acid. The acyl chloride group undergoes rapid nucleophilic substitution, making it an essential building block for custom pharmaceuticals, peptides, and advanced polymer synthesis.

Quality & Compliance

Sourced from our state-of-the-art facility, our Methyl Adipoyl Chloride maintains a purity of >=98.0% verified by GC.

Storage & Packaging

It must be stored under a dry nitrogen blanket in specialized corrosion-resistant containers in a cool, dry area to maintain product integrity.

Safety & Protocols

Since it reacts violently with water and moisture to release corrosive hydrochloric acid gas, strict isolation and acid-resistant PPE are mandatory.

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