9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one
High-Purity 9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one The Primary Key Starting Material (KSM) for Ondansetron API Manufacturing. (CAS 27387-31-1).
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High-Purity 9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one The Primary Key Starting Material (KSM) for Ondansetron API Manufacturing. (CAS 27387-31-1).
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9-Methyl Carbazolone (9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one) is the critical key starting material (KSM) for the commercial scale manufacturing of Ondansetron (Zofran), the widely prescribed anti-emetic therapy. Sourcing this intermediate from a dedicated API Intermediate Manufacturer like Kalpasthana ensures the N-methyl group is pre-installed under high-purity synthesis conditions, removing late-stage alkylation steps and optimizing downstream yields. We provide complete regulatory documentation and custom synthesis capabilities to support global pharmaceutical supply chains.
Manufacturing Importance: Sourced directly from our state-of-the-art facility in Bidar District, Karnataka. Every batch is manufactured under strict quality controlled guidelines, ensuring predictable synthesis yields and batch-to-batch consistency.
Sourced directly from our state-of-the-art facility in Bidar District, Karnataka. Every batch is manufactured under strict quality controlled guidelines, ensuring predictable synthesis yields and batch-to-batch consistency.
9-Methyl Carbazolone (9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one) is the critical key starting material (KSM) for the industrial synthesis of Ondansetron (Zofran), the gold standard anti-emetic therapy for chemotherapy and post-operative nausea. It is also utilized as a pharmaceutical scaffold in developing novel anti-tumor agents, CNS-active drugs, and high-performance optoelectronic carbazole derivatives.
During Ondansetron synthesis, 9-methyl carbazolone undergoes a critical Mannich reaction followed by imidazole substitution. Having the N-methyl group pre-installed avoids the need for a late-stage methylation step, streamlining the manufacturing process and ensuring consistent stereochemical outcomes in the final API.
Direct precursor which undergoes Mannich reaction and subsequent imidazole coupling to yield Ondansetron API.
Serves as a key carbazole framework in research targeting neuroprotective and anti-psychotic drug development.
Specifically synthesized for stable long-term storage and high chemical yields in downstream manufacturing processes.
For 9-Methyl Carbazolone, quality is our foundational pillar. We ensure high-purity N-alkylated carbazole footprints through strict process controls and specialized crystallization techniques. Our laboratory specifically monitors organic synthesis steps to limit related carbazole and demethylated impurities, ensuring batch-to-batch consistency for Ondansetron API manufacturing.
Every shipment is backed by in-house HPLC purity verification (maintaining assay purity >=99.0%), GC-MS impurity profiling, and complete Certificates of Analysis (COA) to support client B2B audits and regulatory compliance.
Manufactured under strict GMP-compliant standard operating procedures.
In-house analytical testing ensuring HPLC purity >=99.0% for every batch.
Complete B2B regulatory paperwork, technical dossiers, and audit support.
Manufactured under strict GMP-compliant standard operating procedures.
In-house analytical testing ensuring HPLC purity >=99.0% for every batch.
Complete B2B regulatory paperwork, technical dossiers, and audit support.
9-Methyl Carbazolone (9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one) is synthesized by the N-methylation of 1,2,3,9-tetrahydrocarbazolone using methylating agents such as dimethyl sulfate or methyl iodide under basic phase-transfer conditions.
It is the immediate precursor to the API Ondansetron. The compound is reacted with formaldehyde and 2-methylimidazole in a Mannich-type reaction to form the final Ondansetron structure. Its high purity is essential to minimize drug-substance impurities.
We manufacture 9-Methyl Carbazolone to a purity of ≥99.0% by HPLC, with strict controls on residual solvents and N-demethylated impurities (less than 0.2%).
It is stored in fiber drums under cool, dry conditions. Sourcing packages include full chromatographic validation.
Avoid exposure. Wear appropriate protective clothing, gloves, and safety goggles. Ensure local exhaust ventilation is operational.
HPLC purity verified at >=99.0% with minimal related substances.
Continuous commercial-scale volume manufacturing capacity.
Complete analytical profiles, GC profiles, MSDS, and COA dossiers.
Equipped with a 50 kL combined reactor volume in Karnataka.
Kalpasthana Life Care Products, Plot no 105, Part A, KIADB Industrial Area, Humnabad, Bidar District, Karnataka, India - 585330
GMP-compliant state-of-the-art facility, rigorous HPLC purity standards ≥99.0%.
Standard 25 kg HDPE fiber drums with double polythene inner bags; custom B2B packaging available.
Commercial Sourcing & Synonyms: Sourcing CAS No. 27387-31-1 from a dedicated carbazole derivatives supplier guarantees high quality. This 9-Methyl carbazol-4-one is a key carbazol-4-one derivative and pharmaceutical intermediate. As a leading fine chemicals manufacturer, Kalpasthana produces heterocyclic compounds and anti-emetic intermediates. We operate as a premier pharma intermediates India exporter and Bulk Drug Intermediates supplier India partner.
9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one (9-Methyl Carbazolone) is the primary Key Starting Material (KSM) for the industrial synthesis of Ondansetron (Zofran). Sourcing high-purity KSM directly influences the reaction efficiency of the subsequent amine condensation and final API yield.
We manufacture 9-Methyl Carbazolone with an HPLC purity of ≥99.0%, controlled via strict gas chromatography (GC) and high-performance liquid chromatography (HPLC) methods. Impurity thresholds are strictly kept within pharmacopeia limits. Batch COA, MSDS, and HPLC chromatograms are standard with all shipments.
Sourced from our ISO-compliant manufacturing plant in Karnataka, India, it is packed in standard 25 kg HDPE fiber drums with double polythene bags. We offer custom packaging, scaling up to multi-ton commercial contracts with robust lead-time commitments.
9-Methyl Carbazolone (9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one) is the critical key starting material (KSM) for the commercial scale manufacturing of Ondansetron (Zofran), the widely prescribed anti-emetic therapy. Sourcing this intermediate from a dedicated API Intermediate Manufacturer like Kalpasthana ensures the N-methyl group is pre-installed under high-purity synthesis conditions, removing late-stage alkylation steps and optimizing downstream yields. We provide complete regulatory documentation and custom synthesis capabilities to support global pharmaceutical supply chains.
Manufacturing Importance: Sourced directly from our state-of-the-art facility in Bidar District, Karnataka. Every batch is manufactured under strict quality controlled guidelines, ensuring predictable synthesis yields and batch-to-batch consistency.
9-Methyl Carbazolone (9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one) is the critical key starting material (KSM) for the industrial synthesis of Ondansetron (Zofran), the gold standard anti-emetic therapy for chemotherapy and post-operative nausea. It is also utilized as a pharmaceutical scaffold in developing novel anti-tumor agents, CNS-active drugs, and high-performance optoelectronic carbazole derivatives.
During Ondansetron synthesis, 9-methyl carbazolone undergoes a critical Mannich reaction followed by imidazole substitution. Having the N-methyl group pre-installed avoids the need for a late-stage methylation step, streamlining the manufacturing process and ensuring consistent stereochemical outcomes in the final API.
For 9-Methyl Carbazolone, quality is our foundational pillar. We ensure high-purity N-alkylated carbazole footprints through strict process controls and specialized crystallization techniques. Our laboratory specifically monitors organic synthesis steps to limit related carbazole and demethylated impurities, ensuring batch-to-batch consistency for Ondansetron API manufacturing.
Every shipment is backed by in-house HPLC purity verification (maintaining assay purity >=99.0%), GC-MS impurity profiling, and complete Certificates of Analysis (COA) to support client B2B audits and regulatory compliance.
Manufactured under strict GMP-compliant standard operating procedures.
In-house analytical testing ensuring HPLC purity >=99.0% for every batch.
Complete B2B regulatory paperwork, technical dossiers, and audit support.
Global pharmaceutical sourcing teams partner with Kalpasthana due to our chemical manufacturing expertise, infrastructure reliability, and strict compliance alignment:
9-Methyl Carbazolone (9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one) is synthesized by the N-methylation of 1,2,3,9-tetrahydrocarbazolone using methylating agents such as dimethyl sulfate or methyl iodide under basic phase-transfer conditions.
It is the immediate precursor to the API Ondansetron. The compound is reacted with formaldehyde and 2-methylimidazole in a Mannich-type reaction to form the final Ondansetron structure. Its high purity is essential to minimize drug-substance impurities.
We manufacture 9-Methyl Carbazolone to a purity of ≥99.0% by HPLC, with strict controls on residual solvents and N-demethylated impurities (less than 0.2%).
It is stored in fiber drums under cool, dry conditions. Sourcing packages include full chromatographic validation.
Avoid exposure. Wear appropriate protective clothing, gloves, and safety goggles. Ensure local exhaust ventilation is operational.
| Chemical Synonyms | 9-methyl-carbazol-4-one, Ondansetron intermediate, Ondansetron Related Compound C, Ondansetron KSM |
|---|---|
| Manufacturing Location | Kalpasthana Life Care Products, Plot no 105, Part A, KIADB Industrial Area, Humnabad, Bidar District, Karnataka, India - 585330 |
| Compliance & Quality | GMP-compliant state-of-the-art facility, rigorous HPLC purity standards ≥99.0%. |
| Commercial Packaging | Standard 25 kg HDPE fiber drums with double polythene inner bags; custom B2B packaging available. |
Commercial Sourcing & Synonyms: Sourcing CAS No. 27387-31-1 from a dedicated carbazole derivatives supplier guarantees high quality. This 9-Methyl carbazol-4-one is a key carbazol-4-one derivative and pharmaceutical intermediate. As a leading fine chemicals manufacturer, Kalpasthana produces heterocyclic compounds and anti-emetic intermediates. We operate as a premier pharma intermediates India exporter and Bulk Drug Intermediates supplier India partner.
9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one (9-Methyl Carbazolone) is the primary Key Starting Material (KSM) for the industrial synthesis of Ondansetron (Zofran). Sourcing high-purity KSM directly influences the reaction efficiency of the subsequent amine condensation and final API yield.
We manufacture 9-Methyl Carbazolone with an HPLC purity of ≥99.0%, controlled via strict gas chromatography (GC) and high-performance liquid chromatography (HPLC) methods. Impurity thresholds are strictly kept within pharmacopeia limits. Batch COA, MSDS, and HPLC chromatograms are standard with all shipments.
Sourced from our ISO-compliant manufacturing plant in Karnataka, India, it is packed in standard 25 kg HDPE fiber drums with double polythene bags. We offer custom packaging, scaling up to multi-ton commercial contracts with robust lead-time commitments.
We are a leading API intermediate manufacturer in India, committed to delivering top-quality pharmaceutical and healthcare solutions globally.