Plot no 105, Part A, Karnataka Industrial Area Development Board, Humnabad, Karnataka 585330

9-Methyl Carbazolone (9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one) Manufacturer India

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High-Purity 9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one (CAS 27387-31-1). The Primary Key Starting Material (KSM) for Ondansetron API Manufacturing.

Chemical Structure of 9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one

9-Methyl Carbazolone (Ondansetron Related Compound C)

CAS No: 27387-31-1

A high-purity pharmaceutical intermediate (commonly referred to as 9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one or 9-methyl-carbazol-4-one) used as a key starting material (KSM) for Ondansetron synthesis.

This modified carbazole derivative is essential for the production of Ondansetron, a highly effective anti-emetic drug. Kalpasthana Life Care Products ensures rigorous quality control and high purity to support efficient API manufacturing.

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Product Specifications

Product Name 9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one
Synonyms / Abbreviations 9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one, Ondansetron Related Compound C, 9-Methylcarbazolone
CAS Number 27387-31-1
Molecular Formula C13H13NO
Molecular Weight 199.25 g/mol
Appearance White to Off-white Crystalline Powder
Purity (HPLC) ≥ 99.0%
Melting Point 88°C - 92°C

Applications & Usage

9-Methyl Carbazolone (9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one) is the critical key starting material (KSM) for the industrial synthesis of Ondansetron (Zofran), the gold standard anti-emetic therapy for chemotherapy and post-operative nausea. It is also utilized as a pharmaceutical scaffold in developing novel anti-tumor agents, CNS-active drugs, and high-performance optoelectronic carbazole derivatives.

Key Features

  • Ondansetron API KSM: Direct precursor which undergoes Mannich reaction and subsequent imidazole coupling to yield Ondansetron API.
  • Advanced CNS Therapeutics: Serves as a key carbazole framework in research targeting neuroprotective and anti-psychotic drug development.
  • High Thermal Stability: Specifically synthesized for stable long-term storage and high chemical yields in downstream manufacturing processes.

Product Specifications & Procurement FAQs

Detailed quality specifications, compliance data, and procurement answers for pharma sourcing professionals.

Quality & Technical Specifications

Chemical Synonyms 9-methyl-carbazol-4-one, Ondansetron intermediate, Ondansetron Related Compound C, Ondansetron KSM
Manufacturing Location Kalpasthana Life Care Products, Plot no 105, Part A, KIADB Industrial Area, Humnabad, Bidar District, Karnataka, India - 585330
Compliance & Quality GMP-compliant state-of-the-art facility, rigorous HPLC purity standards ≥99.0%.
Commercial Packaging Standard 25 kg HDPE fiber drums with double polythene inner bags; custom B2B packaging available.

Frequently Asked Questions

What is the commercial importance of 9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one (CAS 27387-31-1) in anti-emetic manufacturing?

9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one (9-Methyl Carbazolone) is the primary Key Starting Material (KSM) for the industrial synthesis of Ondansetron (Zofran). Sourcing high-purity KSM directly influences the reaction efficiency of the subsequent amine condensation and final API yield.

What are the chemical specifications and purity testing protocols for 9-Methyl Carbazolone?

We manufacture 9-Methyl Carbazolone with an HPLC purity of ≥99.0%, controlled via strict gas chromatography (GC) and high-performance liquid chromatography (HPLC) methods. Impurity thresholds are strictly kept within pharmacopeia limits. Batch COA, MSDS, and HPLC chromatograms are standard with all shipments.

What are the B2B supply logistics and packaging standards for 9-Methyl Carbazolone?

Sourced from our ISO-compliant manufacturing plant in Karnataka, India, it is packed in standard 25 kg HDPE fiber drums with double polythene bags. We offer custom packaging, scaling up to multi-ton commercial contracts with robust lead-time commitments.

Technical Profile & Sourcing Guide

Comprehensive chemical specs, catalytic pathways, and quality compliance guidelines for raw materials sourcing.

Chemical Synthesis

9-Methyl Carbazolone (9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one) is synthesized by the N-methylation of 1,2,3,9-tetrahydrocarbazolone using methylating agents such as dimethyl sulfate or methyl iodide under basic phase-transfer conditions.

Applications & Pathways

It is the immediate precursor to the API Ondansetron. The compound is reacted with formaldehyde and 2-methylimidazole in a Mannich-type reaction to form the final Ondansetron structure. Its high purity is essential to minimize drug-substance impurities.

Quality & Compliance

We manufacture 9-Methyl Carbazolone to a purity of ≥99.0% by HPLC, with strict controls on residual solvents and N-demethylated impurities (less than 0.2%).

Storage & Packaging

It is stored in fiber drums under cool, dry conditions. Sourcing packages include full chromatographic validation.

Safety & Protocols

Avoid exposure. Wear appropriate protective clothing, gloves, and safety goggles. Ensure local exhaust ventilation is operational.

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