Plot no 105, Part A, Karnataka Industrial Area Development Board, Humnabad, Karnataka 585330

4-Hydroxycarbazole (4-Hydroxy-9H-carbazole) Manufacturer India

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Premium Heterocyclic Intermediate specifically designed for Carvedilol API Production.

Chemical Structure of 4-Hydroxycarbazole

4-Hydroxycarbazole (4-Carbazolol)

CAS No: 52602-39-8

Premium Heterocyclic Intermediate specifically designed for Carvedilol API Production.

A specialized heterocyclic isomer (commonly known as 4-Hydroxy-9H-carbazole, 4-Carbazolol, or 9H-Carbazol-4-ol) and high-purity intermediate specifically designed for the synthesis of the cardiovascular drug Carvedilol.

This specific isomer is primarily utilized in the synthesis of Carvedilol for heart failure management. Our production process focuses on maximizing the purity of the 4-hydroxy isomer while minimizing by-products for superior pharmaceutical quality.

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Product Specifications

Product Name 4-Hydroxycarbazole
Synonyms / Abbreviations 4-Hydroxy-9H-carbazole, 4-Carbazolol, 9H-Carbazol-4-ol, Carvedilol Intermediate
CAS Number 52602-39-8
Molecular Formula C12H9NO
Molecular Weight 183.21 g/mol
Appearance White to Light Brown Powder
Purity (HPLC) ≥ 99.0%
Melting Point 165°C - 168°C

Applications & Usage

4-Hydroxycarbazole is a pivotal heterocyclic intermediate specifically manufactured for the synthesis of Carvedilol, a non-selective beta-blocker/alpha-1 blocker for hypertension and heart failure. Additionally, it serves as a key building block for carbazole-based organic semiconductors, high-performance optical materials, antioxidants, and anti-inflammatory compounds under therapeutic research.

Key Features

  • Carvedilol API Precursor: Undergoes selective epoxidation with epichlorohydrin to form epoxy propoxy carbazole, the direct precursor to Carvedilol.
  • Isomeric Precision: Strictly monitored manufacturing to ensure ultra-low levels of the 2-hydroxy isomer, maximizing downstream chemical yields.
  • Material Science & Electronics: Precursor for photorefractive polymers, holographic materials, and high-stability OLED hole transport layers.

Product Specifications & Procurement FAQs

Detailed quality specifications, compliance data, and procurement answers for pharma sourcing professionals.

Quality & Technical Specifications

Chemical Synonyms 4-Hydroxy-9H-carbazole, 4-Carbazolol, 9H-Carbazol-4-ol, Carvedilol intermediate
Manufacturing Location Kalpasthana Life Care Products, Plot no 105, Part A, KIADB Industrial Area, Humnabad, Bidar District, Karnataka, India - 585330
Compliance & Quality GMP-compliant state-of-the-art facility, rigorous HPLC purity standards ≥99.0%.
Commercial Packaging Standard 25 kg HDPE fiber drums with double polythene inner bags; custom B2B packaging available.

Frequently Asked Questions

Why is 4-Hydroxycarbazole (CAS 52602-39-8) critical for Carvedilol synthesis?

4-Hydroxycarbazole (also known as 4-Carbazolol or 9H-Carbazol-4-ol) is the direct precursor to Carvedilol, a widely prescribed beta-blocker. The carbazole ring and the hydroxyl group at the 4-position undergo highly selective epoxidation, making it the most cost-effective and chemically stable starting point for this API synthesis.

What quality controls and purity assurances does Kalpasthana offer for 4-Hydroxycarbazole?

Kalpasthana ensures a high purity profile for 4-Hydroxycarbazole of ≥99.0% by HPLC. We strictly monitor critical impurities like 2-hydroxycarbazole and other positional isomers to ensure the safety and efficacy of the final API. Full technical packages (MSDS, COA, DMF support) are available for B2B audits.

What are the safety, storage, and commercial packaging specifications for 4-Hydroxycarbazole?

The compound is packed in 25 kg HDPE fiber drums with double poly-bags. Since it is sensitive to oxidation and light, it must be stored in tightly closed, light-resistant containers. We maintain ready bulk stocks to support long-term supply contracts for global pharmaceutical companies.

Technical Profile & Sourcing Guide

Comprehensive chemical specs, catalytic pathways, and quality compliance guidelines for raw materials sourcing.

Chemical Synthesis

4-Hydroxycarbazole (9H-carbazol-4-ol) is a phenolic carbazole derivative. It is synthesized industrially by the dehydrogenation and subsequent aromatization of 1,2,3,9-tetrahydrocarbazolone using catalysts like palladium on carbon, or via cyclization reactions of diarylamines.

Applications & Pathways

4-Hydroxycarbazole is the essential Key Starting Material (KSM) for Carvedilol. It reacts with epichlorohydrin to yield 4-(2,3-epoxypropoxy)carbazole (Epoxy Propoxy Carbazole), which is then coupled with 2-(2-methoxyphenoxy)ethylamine to produce the final Carvedilol active ingredient.

Quality & Compliance

Our 4-Hydroxycarbazole features a purity of ≥98.0% by HPLC. Each batch is supplied with an analytical testing certificate.

Storage & Packaging

It is highly sensitive to oxidation and must be packed under nitrogen in sealed containers. Storage in a cool, dark place is mandatory to prevent discoloration.

Safety & Protocols

Wear protective equipment, including gloves, face protection, and respiratory dust masks during transfer operations.

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