Plot no 105, Part A, KIADB, Humnabad, Karnataka 585330

Alpha Lipoic Acid (CAS 1077-28-7) Manufacturer India

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High-Purity Alpha Lipoic Acid (Thioctic Acid). A premium organosulfur active pharmaceutical ingredient (API) for dietary supplements and healthcare products.

Chemical Structure of Alpha Lipoic Acid

Alpha Lipoic Acid

CAS No: 1077-28-7

A high-purity active pharmaceutical ingredient and antioxidant (commonly known as Thioctic Acid or Alpha Lipoic Acid) widely used in dietary supplements, diabetic neuropathy therapies, and health formulations.

Alpha Lipoic Acid acts as a universal antioxidant soluble in both water and fat. Commercially, its multi-step synthetic pathway utilizes high-purity intermediates including Methyl Adipoyl Chloride to construct its essential eight-carbon backbone. Kalpasthana Life Care Products manufactures premium grade Alpha Lipoic Acid under strict GMP quality compliance.

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Product Specifications

Product Name Alpha Lipoic Acid
Synonyms / Alternate Names Thioctic acid, 1,2-Dithiolane-3-pentanoic acid, DL-Thioctic acid, DL-alpha-Lipoic acid, Thioctic acid racemic, 6,8-Thioctic acid
CAS Number 1077-28-7
Molecular Formula C8H14O2S2
Molecular Weight 206.33 g/mol
Appearance Light yellow crystalline powder
Purity (HPLC) ≥ 99.0%
Melting Point 60–62 °C

Applications & Usage

Alpha Lipoic Acid (Thioctic Acid) is a premier universal antioxidant and organosulfur compound. It plays a critical role in cellular energy metabolism as a cofactor for mitochondrial multi-enzyme complexes. It is widely formulated in dietary supplements, therapeutic agents for diabetic neuropathy, anti-aging cosmetics, heavy-metal chelators, and neurodegenerative disease treatments.

Key Features

  • Universal Antioxidant Profile: Soluble in both water and fat, allowing it to neutralize free radicals throughout the entire cell structure.
  • Neuropathy & Metabolic Support: Clinically proven to improve insulin sensitivity and alleviate symptoms of peripheral diabetic neuropathy.
  • Dermatological & Anti-Aging: Widely used in topical formulations to prevent photo-aging, reduce skin inflammation, and support collagen structure.

Product Specifications & Procurement FAQs

Detailed quality specifications, compliance data, and procurement answers for pharma sourcing professionals.

Quality & Technical Specifications

Chemical Synonyms Thioctic acid, 1,2-Dithiolane-3-pentanoic acid, DL-Thioctic acid, DL-alpha-Lipoic acid, Thioctic acid racemic, 6,8-Thioctic acid
Manufacturing Location Kalpasthana Life Care Products, Humnabad, Bidar District, Karnataka, India - 585330
Compliance & Quality GMP-compliant state-of-the-art facility, rigorous HPLC purity testing, low residue solvents.
Commercial Packaging Standard commercial fiber drums with double polythene linings; customized B2B sizes.

Frequently Asked Questions

How is Alpha Lipoic Acid synthesized from adipate intermediates?

The industrial synthesis of Alpha Lipoic Acid often starts with Methyl Adipoyl Chloride, which undergoes acylation and reduction to form the carbon skeleton. Subsequent replacement steps introduce the sulfur atoms onto positions 6 and 8, completing the dithiolane ring structure.

What are the storage recommendations for Alpha Lipoic Acid?

Alpha Lipoic Acid is sensitive to light, heat, and oxygen. It must be stored in tightly sealed, light-resistant containers (such as double black poly bags inside fiber drums) at cool temperatures, preferably below 25°C.

What regulatory documentation is available for Kalpasthana's Alpha Lipoic Acid?

We provide comprehensive support for bulk buyers, including detailed Certificates of Analysis (COA) highlighting HPLC assay and heavy metal limits, Material Safety Data Sheet (MSDS), DMF technical packages, and allergen statements for food/supplement compliance.

Technical Profile & Sourcing Guide

Comprehensive chemical specs, catalytic pathways, and quality compliance guidelines for raw materials sourcing.

Chemical Synthesis

Alpha Lipoic Acid (Thioctic Acid) features a chiral carbon and an eight-carbon fatty acid chain terminated by a 1,2-dithiolane ring. Its industrial synthesis is a multi-step organic process starting with adipate derivatives such as Methyl Adipoyl Chloride. Acylation of ethylene under Friedel-Crafts conditions followed by reduction, thiolation using sodium sulfide, and catalytic ring closure constructs the essential dithiolane ring.

Applications & Pathways

As a universal antioxidant soluble in both water and lipids, Alpha Lipoic Acid is widely formulated in dietary supplements and nutraceuticals to combat oxidative stress. In the pharmaceutical industry, it is a key API used to treat diabetic neuropathy, support cellular energy production, and improve insulin sensitivity. It is also used in advanced anti-aging skincare formulations due to its ability to neutralize free radicals and regenerate other antioxidants.

Quality & Compliance

Our Alpha Lipoic Acid is a light yellow crystalline powder with a purity of >=99.0% verified by HPLC, meeting international USP/EP pharmacopeia standards.

Storage & Packaging

It must be packed in double black polyethylene bags within fiber drums (25 kg) and stored under cool, dark conditions (below 25°C) to prevent thermal degradation.

Safety & Protocols

It is highly sensitive to light, high temperatures, and oxygen, which can cause polymerization of the dithiolane ring. Use safety goggles and gloves.

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